From:	onbehalfof+aphongdara+gmail.com@manuscriptcentral.com on behalf of 
Pharmaceutical Biology 
[onbehalfof+aphongdara+gmail.com@manuscriptcentral.com]
Sent:	Tuesday, August 09, 2016 1:36 AM
To:	rankovic@kg.ac.rs
Subject:	Pharmaceutical Biology - Invitation to Review Manuscript ID NPHB-2016-
2066

08-Aug-2016

Dear Professor Branislav Rankovic:

The above manuscript, entitled "Extracts of Cladonia subulata and Cladonia 
foliacea display profound anticancer activity and accelerate wound healing" 
with Professor tutar as contact author has been submitted to Pharmaceutical 
Biology.

I would be grateful if you would kindly agree to act as a reviewer for this 
paper.  The abstract appears at the end of this letter, along with the names 
of the authors.

Please let me know as soon as possible if you will be able to accept my 
invitation to review.  To do this please either click the appropriate link 
below to automatically register your reply with our online manuscript 
submission and review system, or e-mail me with your reply.

Agreed: 
https://mc.manuscriptcentral.com/nphb?URL_MASK=c6dfebeb05e9423dbb67e4a21bf0821
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Declined: 
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Unavailable: 
https://mc.manuscriptcentral.com/nphb?URL_MASK=7aaa4bc01a6f44d88b64798f8812607
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I realise that our expert reviewers greatly contribute to the high standards 
of the Journal, and I thank you for your present and/or future participation.

Sincerely,

Prof. Amornrat Phongdara


MANUSCRIPT DETAILS

TITLE: Extracts of Cladonia subulata and Cladonia foliacea display profound 
anticancer activity and accelerate wound healing

AUTHORS: hepokur, ceylan; Misir, Sema; tutar, u?ur; hepokur, ali ihsan; tuzcu, 
mehmet; kocakaya, mustafa; al?c?, mehmet; tutar, yusuf

ABSTRACT: Drug resistance to treatment of diseases result from a variety of 
factors. Plant-derived compounds have found common interest in the search of 
alternative drug compounds. Cladonia species have medical applications as 
antibiotic compounds and have potential as drug candidates for the treatment 
of diseases.
Objective: This work focused on the assessment of wound healing and anticancer 
properties of two Cladonia species possibly with novel mechanisms of action.
Materials and methods: Wound healing activity of Cladonia species were 
evaluated by histological analysis. Antibacterial and antifungal properties of 
Cladonia species extracts were tested by disc diffusion assay while scavenging 
activities were tested by employing 2, 2-diphenyl-1-picrylhydrazyl (DPPH). 
Anticancer activities of the species tested on MG63 (Human of Bone 
Osteosarcoma) and MCF-7 (Breast Carcinoma) cell lines.
Results: The Cladonia-lichens displayed profound activity on wound healing, 
cytotoxicity over cancer cells, free radical scavenging, and antimicrobial 
experiments. Cladonia foliacea extract not only inhibit cancer cell survival 
but also has minimal toxic effects on normal cells however, Cladonia subulata 
displayed toxic effect on both cancer and normal cell lines. This anticancer 
property of the Cladonia foliacea extract provides a template for drug 
development and highlights the importance of plant research for drug design. 
The methanol extracts of lichen species displayed free radical scavenging 
activity as well. Further, extract of Cladonia foliacea displayed 
antimicrobial-antifungal activity and surprisingly Cladonia subulata has no 
effect on antimicrobial-antifungal activity. 
Discussion and conclusion: These findings suggest that the Cladonia species 
extracts are natural antioxidants and novel pharmaceutical compounds for 
potential drug design.



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